{"id":5263,"date":"2024-01-23T11:25:48","date_gmt":"2024-01-23T08:25:48","guid":{"rendered":"https:\/\/blog.inekle.com\/?p=5263"},"modified":"2026-08-25T20:07:37","modified_gmt":"2026-08-25T17:07:37","slug":"fen-bilimleri-alaninda-nobel-odulu-alanlar-bolum-1-aziz-sancar","status":"publish","type":"post","link":"https:\/\/blog.inekle.com\/fen-bilimleri-alaninda-nobel-odulu-alanlar-bolum-1-aziz-sancar\/","title":{"rendered":"Nobel \u00d6d\u00fcl\u00fc Sahipleri: Aziz Sancar"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Merhaba de\u011ferli inekle Blog Okuyucular\u0131! Yeni yaz\u0131 serimize ho\u015f geldiniz. Bu serimizde, fen bilimleri alan\u0131nda Nobel \u00d6d\u00fcl\u00fc alan de\u011ferli bilim insanlar\u0131n\u0131n, bilim d\u00fcnyas\u0131n\u0131n belki de en prestijli \u00f6d\u00fcl\u00fc say\u0131lan Nobel \u00f6d\u00fcl\u00fc alma sebeplerine ve Nobel\u2019e uzanan yolculuklar\u0131na birlikte bakaca\u011f\u0131z.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-58.png\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"678\" src=\"https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-58-1024x678.png\" alt=\"\" class=\"wp-image-5267\" srcset=\"https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-58-1024x678.png 1024w, https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-58-300x199.png 300w, https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-58-768x509.png 768w, https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-58-1536x1017.png 1536w, https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-58-2048x1356.png 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Serimizin ilk yaz\u0131s\u0131nda 2015 y\u0131l\u0131nda kimya alan\u0131nda Nobel \u00d6d\u00fcl\u00fc alarak \u00fclkemizi temsil eden de\u011ferli bilim insan\u0131 Dr. Aziz Sancar\u2019\u0131n Nobel \u00d6d\u00fcl\u00fc\u2019ne uzanan yolculu\u011funu ve Nobel \u00d6d\u00fcl\u00fc almas\u0131n\u0131 sa\u011flayan \u00e7al\u015fmas\u0131ndan bahsede\u011fiz.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>K\u0131sa Biyografi:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0130lk \u00f6nce, Dr. Aziz Sancar hocam\u0131z\u0131n hayat hikayesine k\u0131saca de\u011finelim. Aziz Sancar, 1946 y\u0131l\u0131nda Mardin\u2019de 8 \u00e7ocuklu ailenin 7. \u00e7o\u00e7u\u011fu olarak d\u00fcnyaya gelmi\u015ftir. \u00c7ocuklu\u011funda evinin yak\u0131ndaki tarlada \u00e7al\u0131\u015fm\u0131\u015f olan Aziz Sancar, tarlada \u00e7al\u0131\u015fmad\u0131\u011f\u0131n\u0131 sevmedi\u011fine karar vermi\u015f ve e\u011fitiminin ba\u015flar\u0131ndan itibaren en \u00e7ok \u00f6rnek ald\u0131\u011f\u0131 \u00fc\u00e7 ki\u015finin annesi Meryem, babas\u0131 Abd\u00fclgani ve Gazi Mustafa Kemal Atat\u00fcrk oldu\u011funu belirtmi\u015ftir. Lise 10. s\u0131n\u0131ftayken kimya \u00f6\u011fretmeni, Aziz Sancar\u2019\u0131n kimyas\u0131 \u00e7ok iyi oldu\u011fundan kimyager olmas\u0131n\u0131 \u00f6nermi\u015f ve bunun \u00fczerine Aziz Sancar \u0130stanbul \u00dcniversitesi\u2019nin hem kimya hem de t\u0131p b\u00f6l\u00fcm\u00fc i\u00e7in s\u0131navlara girmi\u015f, iki b\u00f6l\u00fcm i\u00e7in de giri\u015f hakk\u0131 kazanm\u0131\u015f ve arkada\u015flar\u0131n\u0131n y\u00f6nlendirmesiyle lisans e\u011fitimine t\u0131p e\u011fitiminden devam etmi\u015ftir. <\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-57.png\"><img loading=\"lazy\" decoding=\"async\" width=\"512\" height=\"302\" src=\"https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-57.png\" alt=\"\" class=\"wp-image-5266\" srcset=\"https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-57.png 512w, https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-57-300x177.png 300w\" sizes=\"auto, (max-width: 512px) 100vw, 512px\" \/><\/a><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">T\u0131p e\u011fitimi sonras\u0131nda Amerika\u2019da bulunan John Hopkins \u00dcniversitesi\u2019nde biyokimya doktora b\u00f6l\u00fcm\u00fcne kabul alm\u0131\u015f ve ald\u0131\u011f\u0131 NATO-T\u00dcB\u0130TAK doktora bursu sayesinde Amerika\u2019ya doktora e\u011fitimi i\u00e7in gitmi\u015f fakat insanlar\u0131n onu yok saymas\u0131 gibi ya\u015fad\u0131\u011f\u0131 s\u0131k\u0131nt\u0131lardan dolay\u0131 e\u011fitimini b\u0131rak\u0131p Mardin\u2019e geri d\u00f6nm\u00fc\u015ft\u00fcr.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Mardin\u2019e d\u00f6nd\u00fckten 6 ay sonra Amerika\u2019ya geri d\u00f6nm\u00fc\u015f ve Dallas Teksas \u00dcniversitesi\u2019nde prokaryot (geli\u015fmemi\u015f) canl\u0131larda ultraviyole (UV) \u0131\u015f\u0131klar\u0131 sonucu olu\u015fan DNA hasar\u0131n\u0131n tamirinde b\u00fcy\u00fck rol alan fotoliyaz enzimini ke\u015ffeden, \u00e7ok \u00f6nemli bilim insan\u0131 Dr. Rupert\u2019\u0131n laboratuvar\u0131nda \u00e7al\u0131\u015fmaya ba\u015flam\u0131\u015ft\u0131r. <\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><a href=\"https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-60.png\"><img loading=\"lazy\" decoding=\"async\" width=\"259\" height=\"194\" src=\"https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-60.png\" alt=\"\" class=\"wp-image-5269\" style=\"aspect-ratio:1.3350515463917525;width:455px;height:auto\"\/><\/a><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Doktoras\u0131n\u0131 Dr. Rupert\u2019\u0131n laboratuvar\u0131nda tamamlad\u0131ktan sonra Dr. Rupp\u2019un laboratuvar\u0131na laboratuvar teknikeri olarak Yale \u00dcniversitesi\u2019nde \u00e7al\u0131\u015fmaya ba\u015flam\u0131\u015ft\u0131r. Yale \u00dcniversitesi\u2019ndeki \u00e7al\u0131\u015fmalar\u0131 s\u0131ras\u0131nda prokaryot h\u00fccrelerde (spesifik olarak <em>E. coli<\/em> bakterisinde) UV \u0131\u015f\u0131klar\u0131 sonucu olu\u015fan DNA hasar\u0131n\u0131n tamirinde DNA hasar\u0131n\u0131 tespit edip bozulan\/uygun olmayan azotlu organik bazlar\u0131 de\u011fi\u015ftiren, UvrA, UvrB ve UvrC proteinlerinin olu\u015fturdu\u011fu UvrABC eksin\u00fckleaz enzimini bulmu\u015ftur. Ara\u015ft\u0131rmalar\u0131ndan sonra akademik kadroya dahil olmak isteyen Dr. Aziz Sancar hoca, yakla\u015f\u0131k 50 \u00fcniversiteye ba\u015fvurup hepsinden red yedikten sonra Kuzey Carolina \u00dcniversitesi\u2019nde \u00f6\u011fretim \u00fcyesi olarak \u00e7al\u0131\u015fmaya ba\u015flam\u0131\u015ft\u0131r.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-62.png\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"446\" src=\"https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-62.png\" alt=\"\" class=\"wp-image-5271\" srcset=\"https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-62.png 600w, https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-62-300x223.png 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/a><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\"><strong>Nobel Getiren Ara\u015ft\u0131rma:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dr. Aziz Sancar, yukar\u0131da da de\u011findi\u011fimiz gibi, doktora ve doktora sonras\u0131 ara\u015ft\u0131rmalar\u0131nda <em>E.coli <\/em>bakterisinde fotoliyaz enziminin etki mekanizmas\u0131n\u0131 ayd\u0131nlatmada b\u00fcy\u00fck rol oynam\u0131\u015ft\u0131r. Dr. Rupp\u2019un laboratuvar\u0131nda ise UvrABC eksin\u00fckleaz enzimini <em>E.coli<\/em> bakterisinden saf olarak elde etmi\u015f ve bu enzimin DNA hasar\u0131nda bozulan\/uygun olmayan azotlu organik bazlar\u0131 veya n\u00fckleotitleri de\u011fi\u015ftirdi\u011fini ke\u015ffetmi\u015ftir. Akademik hayat\u0131nda ekibiyle Kuzey Carolina \u00dcniversitesi\u2019nde yapt\u0131\u011f\u0131 \u00e7al\u0131\u015fmalar sonucu fotoliyaz enziminin \u00e7al\u0131\u015fmas\u0131nda g\u00f6rev alan FADH<sup> \u2013<\/sup> ve pterin olmak \u00fczere enzmin 2 kromofor (belirli dalga boyunda \u0131\u015f\u0131\u011f\u0131 so\u011furan ve bunun sonucunda bir \u0131\u015f\u0131k yayan molek\u00fcl) ile etkile\u015fime girdi\u011fini ve flavin kofakt\u00f6r\u00fcn\u00fcn enzimin kofakt\u00f6r\u00fc olarak g\u00f6rev ald\u0131\u011f\u0131n\u0131 ke\u015ffederek enzimin \u00e7al\u0131\u015fma mekanizmas\u0131 ile bilgileri geni\u015fletmi\u015ftir. <\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-59.png\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"600\" src=\"https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-59-1024x600.png\" alt=\"\" class=\"wp-image-5268\" srcset=\"https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-59-1024x600.png 1024w, https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-59-300x176.png 300w, https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-59-768x450.png 768w, https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-59-1536x900.png 1536w, https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-59-2048x1201.png 2048w, https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-59.png 1920w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Ayr\u0131ca daha sonradan insanlar\u0131n DNA tamir mekanizmalar\u0131n\u0131n, <em>E.coli<\/em> bakterisinin DNA tamir mekanizmas\u0131na benzer oldu\u011funu ke\u015ffetmi\u015f ve bunla ilgili daha detayl\u0131 \u00e7al\u0131\u015fmalara imza atm\u0131\u015ft\u0131r. Dr. Aziz Sancar, bu \u00e7al\u0131\u015fmalar\u0131 ile, 2015\u2019de DNA tamirindeki mekanik \u00e7al\u0131\u015fmalar\u0131 i\u00e7in ald\u0131\u011f\u0131 Nobel Kimya \u00d6d\u00fcl\u00fc\u2019n\u00fc, ayn\u0131 alanda \u00f6nemli \u00e7al\u0131\u015fmalara imza atm\u0131\u015f Dr. Thomas Lindahl ve Dr. Paul Modrich ile payla\u015fm\u0131\u015ft\u0131r. Dr. Aziz Sancar g\u00fcn\u00fcm\u00fczde ekibiyle beraber, kendi bulup isimlendirdikleri CRY proteinlerinin memelilerin biyolojik saati \u00fczerindeki etkilerini ve bu proteinlerin meyve sineklerinin (<em>Drosophila melanogaster<\/em>) fotoresept\u00f6rleri \u00fczerinden biyolojik saat \u00fczerine etkilerini ara\u015ft\u0131rmaktad\u0131r.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><a href=\"https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-61.png\"><img loading=\"lazy\" decoding=\"async\" width=\"284\" height=\"177\" src=\"https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-61.png\" alt=\"\" class=\"wp-image-5270\" style=\"aspect-ratio:1.6045197740112995;width:492px;height:auto\"\/><\/a><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\"><strong>Kaynaklar:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Aziz Sancar \u2013 Biographical. NobelPrize.org. Nobel Prize Outreach AB 2024. Tue. 9 Jan 2024. <a href=\"https:\/\/www.nobelprize.org\/prizes\/chemistry\/2015\/sancar\/biographical\/\">https:\/\/www.nobelprize.org\/prizes\/chemistry\/2015\/sancar\/biographical\/<\/a><\/li>\n\n\n\n<li>Kresge, Nicole et al. \u201cDNA Repair Mechanisms: the Work of Aziz Sancar.\u201d <em>The Journal of Biological Chemistry<\/em> vol. 284,44 (2009): e19\u2013e20.<\/li>\n\n\n\n<li>The Nobel Prize in Chemistry 2015. NobelPrize.org. Nobel Prize Outreach AB 2024. Tue. 9 Jan 2024. <a href=\"https:\/\/www.nobelprize.org\/prizes\/chemistry\/2015\/summary\/\">https:\/\/www.nobelprize.org\/prizes\/chemistry\/2015\/summary\/<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Bilim i\u00e7in heves ve merakla kalman\u0131z umuduyla bir sonraki yaz\u0131m\u0131zda g\u00f6r\u00fc\u015fmek \u00fczere!<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Beste Dip\u00e7in<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-63.png\"><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/blog.inekle.com\/wp-content\/uploads\/2024\/01\/image-63.png\" alt=\"\" class=\"wp-image-5272\"\/><\/a><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">23.01.2024<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Merhaba de\u011ferli inekle Blog Okuyucular\u0131! Yeni yaz\u0131 serimize ho\u015f geldiniz. Bu serimizde, fen bilimleri alan\u0131nda Nobel \u00d6d\u00fcl\u00fc alan de\u011ferli bilim insanlar\u0131n\u0131n, bilim\u2026<\/p>\n","protected":false},"author":1,"featured_media":5289,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_inekle_views":9,"footnotes":""},"categories":[88],"tags":[708,2122,2559,22,2558,1054,719,711,163,2560,2561,49,154,686,70,151,685],"class_list":["post-5263","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-veliler-icin","tag-ayt","tag-aziz-sancar","tag-bilim-tarihi","tag-canli-ders","tag-fen-bilimleri-alaninda-nobel-odulu-alanlar","tag-inekle-blog","tag-kimya","tag-lgs","tag-lys-tavsiyeleri","tag-nobel-oddulu","tag-nobel-odulu","tag-online-dershane","tag-online-ozel-ders","tag-tyt","tag-universite-tercih","tag-universiteliden-ozel-ders","tag-yks"],"_links":{"self":[{"href":"https:\/\/blog.inekle.com\/wp-json\/wp\/v2\/posts\/5263","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blog.inekle.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.inekle.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.inekle.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.inekle.com\/wp-json\/wp\/v2\/comments?post=5263"}],"version-history":[{"count":1,"href":"https:\/\/blog.inekle.com\/wp-json\/wp\/v2\/posts\/5263\/revisions"}],"predecessor-version":[{"id":11132,"href":"https:\/\/blog.inekle.com\/wp-json\/wp\/v2\/posts\/5263\/revisions\/11132"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blog.inekle.com\/wp-json\/wp\/v2\/media\/5289"}],"wp:attachment":[{"href":"https:\/\/blog.inekle.com\/wp-json\/wp\/v2\/media?parent=5263"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.inekle.com\/wp-json\/wp\/v2\/categories?post=5263"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.inekle.com\/wp-json\/wp\/v2\/tags?post=5263"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}